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direct CNS effects), and refine IIH treatment strategies.

Am J Cancer Res 7(5):10161036 [PMC free article] [PubMed] [Google Scholar] Franceschi C, Garagnani P, Morsiani C, Conte M, Santoro A, Grignolio A, Monti D, Capri M, Salvioli S (2018) The continuum of aging and age-related diseases: common mechanisms but different rates

Importantly, functional analysis showed the transcriptome included nearly all enzymes for key metabolic pathways, specifically 21 of 22 enzymes involved in aromatic amino acid synthesis and all eight enzymes required for branched-chain amino acid (Clouse et al., 2016)

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